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Dermal Infusion & Structural Remodelling System (SRS Treatment)

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One of the most effective ways to deliver active ingredients, antioxidants and medications into the cells and the extracellular matrix is via electrotherapies. For decades, the medical fraternity and the aesthetics industries have used and celebrated the non-invasive effectiveness of applying currents or ultrasound to the skin for maximum absorption of preparations and to regenerate and reanimate biological functions and muscle tone.

Transdermal delivery of ingredients works in a unique way and is dependant on the type of modality of electrotherapy and the molecular weight of the ingredients. The SRS Skin Remodelling System has unique technology where 5 modes of electrotherapy are combined into one handpiece - maximising the effects by creating a synergy between how the energy is delivered.

The SRS is the first transdermal delivery system to simultaneously combine the compounded effects of HVPC, Impulse micro-currents, ultrasound, electroporation and iontophoresis current.

The technology in this treatment is scientifically proven for outstanding results and each of the modes of energy have a slightly different tissue interaction.

 
 
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1. High Voltage Pulsatile Currents

This current is used to repair and renew muscle fibres, improving muscle tone and skin elasticity. The clinical efficacy of this technology is known for it’s comfortable delivery of energy which has a stimulatory effect on the nerves of the muscles and promote muscle contraction. This tones and firms muscle laxity whilst regenerating muscle cell function (Alon, 1987).

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2. Ultrasound

1MHz ultrasound gently heats the tissue in the dermis initiating collagen remodelling and skin tightening. This also allows for movement of molecules between the cells via cavitations or channels and this begins the product delivery. Ultrasound increases the mobility of movement of ingredients through the skin by the vibrational impact sound waves have intercellularly. The energy produced from this vibration generates as heat which has a beneficial relaxation of vasculature stimulating circulation and metabolic processes (Robertson et al., 2006). Phonophoresis or sonophoresis is the method of using ultrasound to create the movement of drugs through the skin to the desired target. Sonophoresis relies on the disturbance of the tissues from the vibrational effects of ultrasound so that molecules can move rapidly between the cells and also into the cells as the cellular membrane becomes disrupted momentarily. Active components are able to be delivered in a very specific way to maximise the impact (Cagnie et al., 2003).

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3. Impulsed microcurrent

Microcurrent stimulates muscle contraction and activates cellular ATP (adenosine triphosphate) which is the “battery” of the cell. Increased ATP production stimulates cellular metabolism which starts to decline with intrinsic and extrinsic ageing factors.

Microcurrent re-educates the muscle fibres and improves blood and lymph flow, restores elasticity, reduces inflammation and erythema, minimises post-surgical recovery time and increases collagen and elastin production (Gerson et al., 2009).

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4. Electroporation

The combination of phonophoresis, electroporation and iontophoresis current is the innovative method of increasing the delivery of active nutrients into the skin at depths never reached before. Electroporation “creates new aqueous pathways” through the lipid bi-layer barrier of cells (Weaver & Chizmadzhev, 2018). This temporary interruption of the cell membrane allows active molecules to enter the cytoplasm where they exert potent positive effects. This is the ultimate in transcellular delivery! 

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5. Iontophoresis (galvanic current)

Iontophoresis is used to “drive” active water soluble particles through the skin without trauma. The penetration is via sweat glands and hair follicles (Robertson et al., 2006). This is specifically important for the delivery of antioxidants and cell renewing peptides into the areas where they are needed most. Particularly beneficial for transcutaneous delivery to treat pigmentary disorders, sun damage and hydration issues.

 

Illustration of the penetration principles of microneedles and sonophoresis (Liu et al., 2023).

Two different methods of skin penetration. Microneedling creates a micro-wound by puncturing the stratum corneum whereas sonophoresis leaves the stratum corneum intact.

Both powerful methods with different mechanisms of action!

Did you know that I can use both in the one treatment for maximum efficacy of transdermal delivery?

Transdermal Delivery - Sonophoresis

Ultrasound or sonophoresis is another non-invasive method of driving active ingredients, medications or formulations into the deeper layers of the skin, without injuring the epidermal barrier function. This modality

How does this work…?

The sonic probe or transducer contains a piezo-electric crystal in the head of the handpiece that when initiated, transmits soundwaves into the skin. Absorption of ultrasound energy in the tissues results in both thermal & non-thermal effects.

Acoustic streaming & micromassage are obtained by pulsing the the sound waves across the skin with a coupling gel which, temporarily makes the skin’s barrier permeable to specifically formulated actives.

Acoustic cavitation is “…the process by which bubbles are created in a fluid when it is acted upon by a force in excess of its tensile strength. Ultrasound propagating through a fluid results in cavitation bubbles…” (Oberlie et al., 2014). This process creates disruption of the stratum corneum (outer most layer of the epidermis), & allows passage of molecules to enter.

This strategy is a well known & evidence based form of transdermal drug delivery, or in the case of dermal regeneration, transdermal infusion delivery of actives.

When the skin barrier is disrupted, the disruption can simultaneously cause epidermal DNA synthesis and increase the release of cytokines, which facilitate the process of tissue repair

The benefits of Low Frequency Sonophoresis (LFS)

  • is an ultrasound based method of transdermal delivery for the passage of actives into the skin to exert a powerful effect

  • recent innovations of LFS include the combinations of other skin barrier permeability methods to increase the absorption through the stratum corneum. This includes combining LFS with iontophoresis, microneedling or with professional resurfacing agents (peels)

  • painless! Completely relaxing to have incorporated into the Prescriptive Tx or as an add onto treating a specific concern

  • No contra-indications….suitable for all skin types

  • is ideal for wound healing strategies, collagen synthesis, impaired circulation & devitalised skins, sensitive skin types & head-to-toe skin health

  • maximises your active ampoule or skin boosters by increasing the rate of absorption & the depth of penetration into the skin by up to 800% (Park et al., 2022).

Transdermal Delivery - Iontophoresis

Iontophoresis is used to “drive” active water soluble particles through the skin without trauma. The penetration is via sweat glands and hair follicles (Robertson et al., 2006). This is specifically important for the delivery of antioxidants and cell renewing peptides into the areas where they are needed most. Particularly beneficial for transcutaneous delivery to treat pigmentary disorders, sun damage and hydration issues.

Electrical modalities can stimulate, change, impede or regenerate cellular functions and aid in repair of skin, muscle and nerve tissue. We utilise direct current as a therapeutic intervention for specific skin concerns or chronic and acute conditions. Galvanic current (as it is also called), allows for the passive movement of substances into the skin. Meaning, the skin remains intact as the active molecules of the substances are moved inbetween the cells, via the skin appendages such as hair follicle, sweat glands and the sebaceous glands (Kumar, Ali & Baboota, 2014). This method of ingredient delivery is still one of the best, non-invasive methods of infusing active substances to their specific target (Manda et al., 2014). This is also called transdermal drug delivery and has been used in medicine, dermatology and aesthetic medicine to improve skin function, treat and manage chronic and acute skin conditions and to restore skin back to health. Some medicines have been specifically designed to be transdermally delivered such as HRT (hormone replacement therapy patches, nicotine patches etc) (Ohshima et al., 2008).

Using galvanic current to infuse products greatly increases the rate and efficiency of absorption and this means that a greater amount of the active ingredient reaches the targeted concern more quickly. Results from this method are longer lasting, more rapid than manual massage infusion and the skin’s health and vitality dramatically improved (Chaulagain et al, 2018).

Iontophoresis is incorporated into the Prescriptive Rx to treat the following conditions:

  • Acne vulgaris (desincrustation and iontophoresis - deeply cleansing and anti-inflammatory)

  • Telangiectasia (Rosacea, sensitivity, diffused erythema/redness)

  • Dehydration concerns

  • Pigmentation concerns (melasma, solar hyperpigmentation/hypomelanosis, post inflammatory hyperpigmentation, scar tissue)

  • Premature ageing (delivery of actives to stimulate collagen production, manage atrophy, hydrate the dermal matrix, restore barrier function)

  • Menopausal skins (strengthens the epidermis, reduces redness and capillary weakness, stimulates collagen production by infusing appropriate active ingredients, restores hydration to the epidermis and generates healthy dermal extracellular matrix)

  • Skin laxity, dullness and asphyxia (lack of oxygen)

Iontophoresis can be used on any area of the body or where the concern occurs. Acne on the back can be assisted greatly by incorporating galvanic therapy into a program. It is a comfortable treatment to have done with zero down time, making it a welcome addition to any targeted dermal therapy.

SRS Treatment (face, neck & decolletage) 75 mins $250

Transdermal Delivery add on with any treatment (20 mins full duty cycle) $79

References +

Cagnie, B., Vinck, E., Rimbaut, S., & Vanderstraeten, G. (2003). Phonophoresis versus topical application of ketoprofen: Comparison between tissue and plasma levels. Physical Therapy, 83, 701-712. doi:10.1093/ptj/83.8.707

Chen, Y., Wang, P., Lai, T., Lu, L., Dai, L., & Wang, C. (2019). Using therapeutic ultrasound to promote irritated skin recovery after surfactant-induced barrier disruption. Ultrasonics, 91, 206-212. https://doi.org/10.1016/j.ultras.2018.08.007

Greenebaum, B., & Barnes, F. (2018). Electroporation. In Biological and Medical Aspects of Electromagnetic Fields, Fourth Edition (4th ed.). Boca Raton, FL: CRC Press.

LIU, T., CHEN, K., YAN, Z., & WANG, Q. (2023). Comparative study of permeation effects between vibrating microneedle and low-frequency Sonophoresis systems. https://doi.org/10.21203/rs.3.rs-3652081/v1 Nelson, R. M., Hayes, K. W., Currier, D. P., & Alon, G. (1999). Principles of electrical stimulation. In Clinical Electrotherapy (pp. 29-80). Upper Saddle River, NJ: Prentice Hall.

Oberli, M. A., Schoellhammer, C. M., Langer, R., & Blankschtein, D. (2014). Ultrasound-enhanced transdermal delivery: Recent advances and future challenges. Therapeutic Delivery, 5(7), 843-857. https://doi.org/10.4155/tde.14.32

Park, D., Won, J., Lee, G., Lee, Y., Kim, C., & Seo, J. (2022). Sonophoresis with ultrasound‐responsive liquid‐core nuclei for transdermal drug delivery. Skin Research and Technology, 28(2), 291-298. https://doi.org/10.1111/srt.13129

Robertson, V. J., Ward, A., Low, J., & Reed, A. (2006). Electrotherapy Explained: Principles and Practice (4th ed.). St. Louis, MO: Elsevier Health Sciences.